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SEI is a group of water soluble iron oxide nanoparticles with amphiphilic polymer and polyethylenimine (PEI) coating. There is no linkable reactive group on the surface of nanoparticles. The zeta potential of SEI is about +10-20 mV. Their organic layers consist of a monolayer of oleic acid, a monolayer of amphiphilic polymer and a monolayer of PEI. The total thickness of the organic layers is about 10 nm. The hydrodynamic size of the nanoparticles is about 20 nm larger than their inorganic core size measured by TEM.

SEI is very stable in most buffer solutions in the pH range of 5-10 and can survive autoclaving process (121 °C for 30 min).

SEI can capture negatively charged molecules, such as DNA, RNA, through charge-charge interaction.
Catalog No.SizeAmount(Fe weight)Particle Amount(nmole) of 1 mg FePrice($) 
SEI-10-0510 nm5 mg0.86249.00
SEI-10-2510 nm25 mg0.86699.00
SEI-15-0515 nm5 mg0.27249.00
SEI-15-2515 nm25 mg0.27699.00
SEI-20-0520 nm5 mg0.11249.00
SEI-20-2520 nm25 mg0.11699.00
SEI-25-0525 nm5 mg0.058249.00
SEI-25-2525 nm25 mg0.058699.00
SEI-30-0530 nm5 mg0.034249.00
SEI-30-2530 nm25 mg0.034699.00
References:
1. L. Yang, X. Peng, Y. A.Wang, X.Wang, Z. Cao, C. Ni, P. Karna, X. Zhang, W. C. Wood, X. Gao, S.Nie, H.Mao. Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer. Clinical Cancer Research, 2009, 15, 4722-4732.
2. L. Yang, H. Mao, Z. Cao Y. A. Wang, X. Peng, X. Wang, H.K. Sajja, L.Wang, H.Duan, C. Ni, C. A Staley, W. C. Wood, X. Gao, S. Nie. Molecular Imaging of Pancreatic Cancer in a Preclinical Animal Tumor Model Using Targeted Multifunctional Nanoparticles. Gastroenterlogy, 2009, 136, 1514-1525.
3. L. Yang, H. Mao, Y. A. Wang, Z. Cao, X. Peng, X. Wang, H. Duan, C. Ni, Q. Yuan, G. Adams, M. Q. Smith, W. C. Wood, X. Gao, S. Nie. Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging. Small, 2009, 5, 235-243.
4. J. Yang, J.Gunn, S. Dave, M.Zhang, Y. A Wang, X. Gao. Ultrasensitive Detection and Molecular Imaging with Magnetic Nanoparticles. The Analysis, 2008, 133, 154–160.
5. H. Duan, M. Kuang, X. Wang, Y. A. Wang, S. Nie, H Mao. Reexamining the effects of particle size and surface chemistry on magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. The Journal of Physical Chemistry C, 2008, 112, 8127–8131.
6. X. Peng, X Qian, H Mao, YA Wang, Z Chen, S Nie, DM Shin. Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International Journal of Nanomedicine, 2008, 3, 311-321.
7. L. Yang, Z. Cao, H. K. Sajja, H. Mao, L. Wang, H. Geng, H. Xu, T. Jiang, W. C. Wood, S. Nie, Y. A. Wang. Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging. Journal of Biomedical Nanotechnology, 2008, 4, 439-449.
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